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KMID : 1134820210500090895
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Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 9 p.895 ~ p.903
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Houttuynia cordata Thunb. Attenuates Hepatic Lipid Accumulation in Diet-Induced Obese Mice
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Cho Su-Jung
Kwon O-Jun
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Abstract
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This study investigated the hepatic lipid-lowering effect of Houttuynia cordata Thunb. (HC) in high-fat diet-induced obese mice. Antioxidant activities were measured using ABTS and DPPH assays in 30% ethanol extract of HC. C57BL/6 mice were classified into five groups: Normal group; 60% high-fat diet group (Control); Control with garcinia cambogia 200 mg/kg/d group (GC200); Control with HC 100 mg/kg/d group (HC100); Control with HC 200 mg/kg/d group (HC200). The DPPH and ABTS free radical scavenging activities of HC extract were estimated to be high (27.90±0.39 and 60.35±1.65 μg/mL, respectively). The high-fat Control diet resulted in significantly increased body weight and liver and epididymal adipose tissue weights compared to Normal diet. Supplementation with GC200 or HC200 reduced body weight, and all three supplementations (GC200, HC100, and HC200) decreased liver weight. Moreover, HC200 lowered epididymal white adipose tissue weight. The three treatments significantly lowered serum triglyceride and total cholesterol (TC) levels. Especially, HC200 showed the strongest serum TC-lowering effect. HC200 also suppressed expression of hepatic lipogenesis proteins (NADPH oxidase 4 (NOX4), p47phox, p22phox, sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthesis (FAS), and stearoyl-CoA desaturase-1 (SCD-1)). As a result, hepatic lipids levels were lowered in the HC200 group. These results suggest that HC200 protects against hepatic lipid accumulation and has an anti-obesity effect.
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KEYWORD
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Houttuynia cordata Thunb., hepatic lipid-lowering effect, anti-obesity, high-fat diet, obese mice
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